Continuity mistake: When the rescue team are jumping from the helicopter to the side of the mountain, the chopper suddenly swings causing Monique to dive for cover. When she dives to the floor there is nothing around her only snow and ice, yet in the following shot when the propeller blades are close to her, a large rock has appeared to her right which wasn't there in the previous shot. (01:00:15)
Factual error: Nitroglycerin does not react with sunlight, nor does it boil in sunlight.
Revealing mistake: When Wick is rubbing his toeless feet, the shot changes so that the camera is behind him and you can see him still rubbing except now you can see that he is simply curling his toes over.
Continuity mistake: When the first climb the "K2" mountain Annie is breathing perfectly without opening her mouth, while the others are gasping for air. She notices she's not breathing hard and all of a sudden her mouth opens wide and she starts gasping too.
Factual error: When the expedition is unloading from the helicopter, it shows a view of the lady with the helicopter blades about to cut her head off. It then shows a view of the helicopter, perfectly upright, and people are still jumping off! She then gets up and crawls to the rock wall, which in a full view you can see that it is at least 15 feet away from the edge. The helicopter blades follow her, perfectly parallel with the ground. It is physically impossible - the helicopter would have to be underground for this to happen.
Continuity mistake: Peter walks into a tent where Monique tells him where to find Skip. The stubble he has when talking to Monique is totally gone when he finds Skip, immediately afterward. (00:16:50)
Character mistake: Those are the most haphazardly secured cases of nitro I've ever seen in a movie. Couldn't they spare a shoelace or duct tape to secure the top?
Factual error: When Annie wants to use the Dexamethasone (glucocorticoid class of hormones produced by the adrenal glands), she takes the box out from her backpack. Climbers normally keeps it warm and close to their body.
Factual error: I don't think it's possible to get so much blood out of a dead body, as they do with McLaren. It's so freezing cold that he should have turned into an ice cube after a whole night at that altitude. Secondly a person who has been dead for a couple of hours does not bleed.
Factual error: When Chris O'Donnell is inside his tent talking on the radio with his trapped sister, they're talking like they're on the telephone, like if they can interrupt each other at will. On a radio, you can only hear the other guy after you've stopped talking. That conversation could never have taken place like that. Besides, they never press the "send" button.
Visible crew/equipment: Just after Vaughn and the others have started there climb up K2, Annie is pulling herself across a rope from one mountain to another. In the reflection of Vaughn's goggles, in his close up, the large white panel and what looks like a camera are visible. (00:29:15)
Continuity mistake: In the first several shots of Wick's frozen wife, her jacket hood sits partway down her forehead. When Wick approaches her, the hood has moved up higher on her head, so you can see her entire forehead and some of her hair.
Continuity mistake: When we see Peter in the hut taking photographs, in the previous shot from a small distance from beyond the two tigers, there is only one large rock then one behind that one. When the shot goes to Peter's camera there is now two small rocks in line with each other. (00:06:35)