Professional photographer L.B. "Jeff" Jeffries (Stewart) breaks his leg while getting an action shot at an auto race. Confined to his New York apartment, he spends his time looking out of the rear window observing the neighbours. He begins to suspect that the man opposite may have murdered his wife. Jeff enlists the help of his society model girlfriend Lisa Freemont (Kelly) and his nurse Stella (Ritter) to help him investigate.