A couple of robbers known as Pumpkin (man) and Honey Bunny (woman) start to rob a restaurant. Vincent Vega and Jules Winnfield are a couple of hitmen who go to an apartment to recover a mysterious briefcase that belongs to their boss Marsellus Wallace, Jules and Vincent kill everybody in the room except Marvin. Butch Coolidge is a boxer about to retire, Marsellus has paid him to throw the fight. Vincent takes Marsellus' wife out at Marsellus' request, her name is Mia. Vincent and Mia have dinner and win a dance contest, then Mia overdoses on heroin and Vincent takes her to his drug dealer friend Lance to save her, she gets saved eventually and they both promise not to tell Marsellus what happened.
A flashback shows young Butch receiving a visit from his dad's friend Captain Koons telling him how Butch's dad died in the Vietnam POW camp and he tells Butch the story of the gold watch that belonged to his great grandfather, then his grandfather and then his dad and now to the next generation being Butch...Captain Koons even had to hide the watch in his ass so it couldn't be detected. Back to the actual time, Butch doesn't throw the fight but he kills the other boxer and escapes with the money, he meets his girlfriend Fabienne who forgot to bring Butch's gold watch from the old apartment so now Butch has to go get it. He goes to his old apartment and finds the watch, but also finds Vincent Vega so he shoots Vincent with a weapon he found in his kitchen. Butch leaves and drives off and finds Marsellus Wallace, the man he stole all the money from, he rolls over Marsellus and hits the car and himself badly.
Marsellus starts to chase him and they get into a fight in a pawn shop where they get knocked unconscious by the owner Maynard. They appear then in the basement tied to chairs. Maynard calls his buddy Zed and they bring out The Gimp, a man all dressed in leather, they take Marsellus to the backroom and leave The Gimp with Butch...Butch manages to set free and knocks out The Gimp, he feels sorry for Marsellus so he grabs a samurai sword from the pawn shop and goes to the back room to find Marsellus being anally raped by Zed. Butch slices Maynard and Zed gets surprised, then Marsellus shoots Zed right in the crotch...Marsellus forgives Butch so Butch goes back to his girlfriend and drive away on Zed's motorcycle.
We now go back in time to see Jules and Vincent in the apartment they first went, after they shot all the guys except Marvin, another guy comes from the bathroom and unloads his gun on Jules and Vincent but he hits nothing, Vincent and Jules shoot him to death and Jules believes they just witnessed a miracle, Vincent doesn't. They take Marvin and drive to Marsellus but they start discussing about the so-called miracle in the car and Vincent accidentally blows Marvin's brains out in the backseat. They storage the car in Jimmie's garage and call The Wolf, an old professional to help them.
The car gets cleaned so Vincent and Jules go to a coffee shop for some breakfast which happens to be the same coffee shop where Pumpkin and Honey Bunny are. Jules tells Vincent he quits the crime so Vincent gets upset and goes to the bathroom, right there Pumpkin and Honey Bunny start to rob the restaurant causing panic among the customers, Pumpkin points the gun at Jules and tells him to open the briefcase he has, he opens it and a mysterious glow amazes Pumpkin, in his distraction Jules pulls his gun against Pumpkin's neck and makes him sit and relax, Honey Bunny points the gun at Jules and then Vincent, who just came out of the bathroom, points the gun at Honey Bunny. Jules gives a biblical speech and lets Pumpkin and Honey Bunny go. Vincent and Jules pack their guns and leave the coffee shop.