Continuity mistake: There is a scene where the female trucker is driving her truck and she intentionally hits a brown car. The problem is that she had already passed by this brown car a few seconds ago when David was getting into her truck through the window.
Continuity mistake: Before his first transformation, David is wearing a white and blue striped shirt with blue jeans. During his transformation he is wearing a red and blue square motif shirt with brown pants. When fully transformed into the Hulk, he is wearing blue jeans again. But when he's removing the rocks to free the professor seconds later, he is wearing a different kind of brown pants. Finally he's wearing blue jeans again for the rest of this first transformation.
Continuity mistake: When David is in the telephone booth trying to call the police he mentions that he can only read the first few digits of the phone number. Then there is a shot of the center of the dial which is almost all black and we cannot read any digit. A few seconds later another shot shows the center of the dial which is now white and we are able to read the first few digits.
Continuity mistake: When the Hulk throws Mr. Malone in the river during his second transformation, the first shot is too long and we see that he would fall a few feet from the closest river shore. But in the second shot he is flying like crazy and almost lands on the remote river shore.
Revealing mistake: During his first transformation, the Hulk gets behind two soldiers and smiles twice. His second smile is too broad and reveals a very shiny silver tooth filling on his right lower jaw. David does have fillings but they do not cover the external area of the teeth (Ref: when he hugs Katie at the end of the 2nd part of Prometheus, right after his last transformation).