You Don't Want to Know - S4-E8
Factual error: Dr. House argues that the symptoms of the patient (DIC, bleeding, and multisystem failure) can be explained by the fact that they gave him the wrong type of blood (type AB). House says the reason they could make such a mistake is that they don't test blood type, they test antibodies. Dr. Foreman responds it's because the human body only makes those antibodies when you have that type of blood. This part is incorrect. In fact, it's the exact opposite. You only produce antibodies against the antigens that you DO not have. If you did, your immune system would attack your own red blood cells (RBCs), which would cause autoimmune hemolytic anemia (aiha). For example, if your blood type is A, you make antibody B and vice versa. A person with blood type AB has A and B antigens on the RBCs, but does not produce antibodies A or B and is therefore a universal recipient. Ironically, the latter is also mentioned by Dr. Wilson in a conversation with House earlier in the episode when he says "Of course you're type AB - universal recipient. You take from everybody." House then says that the patient has blood type A, but he's making an extra antibody of type B, which led them to believe he has blood type AB and therefore give him type AB blood. House then deduces that this caused the immunologic reaction, leading to the diagnosis, SLE (lupus), which can cause acquired aiha. It's correct that giving type AB blood to a person with blood type A would cause this, but the first part is wrong. If he is type A, he is supposed to make antibody B, not antibody A, so if he were making an extra antibody, it would be antibody A, not antibody B. (00:38:20)
Factual error: In episode 414, "Living the Dream," the patient Evan is given a nerve function test. We see Kutner and Taub performing the test by puncturing Evan's legs with needles. Modern nerve function tests actually rely on electrical impulses from a small computerized device, with no needles necessary.
Suggested correction: House ordered an EMG (electromyography) to test for motor nerve entrapment. During an EMG, one or more small needles (electrodes) are inserted through the skin into the muscle. The electrical activity picked up by the electrodes is then displayed on an oscilloscope. An audio amplifier is used so the activity can be heard. When an electrode is inserted, a brief period of activity can be seen on the oscilloscope, but after that, no signal should be present.
Factual error: House diagnoses contagious ecthyma in a patient exposed to a donkey. This zoonosis is however NOT transmitted by donkeys. "Contagious ecthyma virus causes papillomatous lesions on lips and mouth, and sometimes on the interdigital areas of primarily young sheep and goats. The hosts of contagious ecthyma virus are sheep, goats, alpacas, chamois, Rocky Mountain Bighorn sheep, Doll sheep, steenbok, wild thar, dog, camel, reindeer, musk ox, and man." https://doi.org/10.1016/B978-0-12-524180-9.50039-X. (00:27:07 - 00:27:40)
Factual error: In an episode with a severely overweight patient who is thought to have diabetes, it is discovered he instead has Chagas disease. Cameron then informs the patient that he acquired this illness from his food when, in fact, Chagas disease is a protozoan that is spread through the bite of the triatomine bug.
Suggested correction: While the main vector for the infection is through the triatomine bug, Trypanosoma cruzi (the parasitic organism that causes the disease) can be transmitted through food, and thus Chagas was caused by the food the patient ate. It should also be noted that Trypanosoma cruzi is not transmitted by the bite of the triatomine bug, but rather through its feces, and it's only spreads once the feces enters the blood stream (which it can do through a bite site or scratching an open wound).
You Don't Want to Know - S4-E8
Factual error: Amber triggers a fire alarm by heating the sprinkler with her lighter. Unfortunately that fire sprinkler doesn't detect heat (or smoke). The sensor is located between the ceiling lamps, about two meters from the fire sprinkler. (00:09:00)
Suggested correction: Heat applied to the sprinkler would cause it to activate and spray water. All modern fire systems will detect this water pressure drop and activate the alarm.
