Continuity mistake: When Bree Van De Kamp is sitting on the couch talking to her marriage counselor, as she is doing so she picks up her purse and puts it on her lap, crossing her hands over it. When the camera switches back to her a second later the purse is back on the couch beside her in the exact position it was in before she picked it up.
Continuity mistake: During the scene where Gaby and John are in her bedroom talking, she takes a drag from her cigarette while John asks why she isn't happy, but never exhales the smoke from that drag. 23 seconds pass from that drag to the next one and she's in frame the entire time (it cuts between shots of the two of them together and Gaby's close-ups, but doesn't cut away from her). It's also worth noting that Gaby is never seen smoking again at any other point in the series and no explanation is given as to why.
Continuity mistake: When Karl is speaking to Susan whilst she's in the towel, we see in one shot his chin is resting on his palm, then when the shot changes he tilts his head and then moves his fingers to his chin then when the shot changes his chin is resting on his palm again.