Continuity mistake: At the very beginning of the episode, the subtitle says, 'Bordeaux, 1900', pertaining to the origin of the grapes which would make 'a wine fit for the Holy Father himself'. When Manny picks up said bottle later in the episode, the label says, 'Appellation Bourgogne Controlée', which means the wine was made in Burgundy, and not Bordeaux.
Continuity mistake: Simon Pegg's character shouts at Manny as he is picking up a muffin, and he slams it onto the desk, smashing it and making a large messy pile of crumbs. The shot changes, then changes back so you can see the muffin (in the same scene) and it is a perfectly formed, whole muffin with no crumbs around. Then when Fran shows up and Pegg's character leaves, the muffin is back to being a messy mound.
Bernard: I can feel pieces of my brain falling away like a wet cake.
Trivia: Fran's last name is Katzenjammer, which is German for "A momentarily severe hangover". It translates literally as "cat misery".