Plot hole: The plot gets confusing here. First, Laura and Jack (the dog) are rabidly bitten by Jasper (her pet racoon). The doctor warns they may have rabies from the bite. A second more dangerous raccoon is discovered which eventually left the area. In the end, Charles (discovering there were two raccoons in the barn after finding Jasper remaining), says Laura is going to be OK after all. The main confusion is that Laura would still be in danger from the bite regardless of which untested raccoon bit her.
Continuity mistake: When Edwards is first discovered missing by Grace, the moon is in the background in the center of the screen. After all the time that goes by with Edwards in the casino, Charles looking for him, finds him and goes all the way back to where they were sleeping (figure at least an hour or more), the moon is still in the exact same position in center of screen from the exact same camera angle. In reality, the moon would have been more to the right or disappeared completely by now (depending on the timespan).
Other mistake: Charles has just brought Adam a letter to the site of the blind school rebuild. When Adam is told that his father died, he and Mary walk away from Charles. The terrain was very uneven. Being blind they realistically wouldn't be able to navigate it without stumbling.
Character mistake: Almanzo says he hasn't seen his brother Royal in 10 years, but in fact he saw him not long ago as he looked after his 2 sons who were terrors, and at that time Royal didn't even have a daughter.
Other mistake: At the very end, Mr. Hanson is seen walking toward the church. Because of his stroke, he's slow and unsteady. We see several close-ups of his feet, showing how he's struggling. Two of those shots are the same footage. It's obvious, because you see that he drags his foot over a small stick in the road and stumbles - and in both shots, it is exactly the same.
Continuity mistake: Charles is delayed getting home on his wedding anniversary because a wheel on his wagon broke, he had no jack and he had to make repairs during a heavy rainstorm. Rain is still falling late at night and can be seen through the window when Caroline hears Charles arriving. She runs outside to greet him and suddenly there is no rain.
Continuity mistake: At the end, when Lars Hanson hears the church bell ringing, he gets up from his bed and goes to look out the window. When he first gets up, his hair is completely tousled - definite "bed head." The shot changes to show him leaning out the window, and his hair is neatly combed. When the shot returns to the inside of the room, his hair is once again rumpled and untidy.