Continuity mistake: In the scene where the grandma is talking at the table with Reese and Malcolm, notice the bottle on the table next the the grandma, between takes the cork from the bottle goes from being on top of the bottle to next to the bottle, it changes in almost every different shot.
Continuity mistake: When Malcolm is trying to get the TV back to the channel he was watching, he picks up a big remote and finds the channel which the video camera feed is on, but the remote he is holding on the TV is a smaller one. It then cuts back to Malcolm who is moving his hand away from the remote he just put down and it's the bigger one again.
Continuity mistake: Season 6, episode 7: "Hal Sleepwalks"; At school, Dewey stops the shouting match between the two opponents. In the shots facing Dewey, the boy's arms are held way up high in front of him, but in the shots facing the kids, the boy's arms are down at his sides.
Continuity mistake: Episode 16 Season 6 "No Motorcycles." Francis calls Hal out to the driveway where two motorcycles are parked. In the first camera shot the motorcycles are parked side by side with the front wheels turned in the same direction. All subsequent shots of the motorcycles in the driveway show them in a different position, one angled behind the other, with the front wheels turned in opposite directions.
Continuity mistake: In the episode where Lois takes revenge on the four girls who pranked Reese, Lois and Reese use a makeshift catapult to launch paint balloons at one of the girls and her date. The first balloon hits the girl, covering her left shoulder with pink paint. In the shot where her date gets hit with a balloon, her shoulder is no longer covered in paint. Some of the paint blotches change size and shape on both her and her date throughout this scene as well.
Continuity mistake: Malcolm's seat belt changes from on to off the first scene with him and his mom in the car. When it's a shot from the front it's on, but when it's a shot from the side (from the driver's/mom side) you can see that the part of the seat belt that's going across is now behind Malcolm, instead of on him like it was a second ago. This changes back and forth.
Continuity mistake: In the scene where Lois finds out about Francis escaping, there are three orange mugs hanging from a rack by the phone. When Lois reaches for the phone to call the police, she makes the middle one start swinging. She and Hal sit down, and the end mug has moved from the rack into a box on the kitchen counter. Also, the mugs are hanging still. Towards the end of the scene, the "fallen" mug is back on the rack, and the middle mug is swinging again.
Continuity mistake: When the "Krelborne" teacher comes to the house to tell Lois that Malcolm is gifted, Lois comes to the door naked and puts her arm up on the doorway. On the shot from behind she has her hand low (about where her waist is) from the shot from the front she has her hand up high (above her head).