Continuity mistake: In the episode where Lois takes revenge on the four girls who pranked Reese, Lois and Reese use a makeshift catapult to launch paint balloons at one of the girls and her date. The first balloon hits the girl, covering her left shoulder with pink paint. In the shot where her date gets hit with a balloon, her shoulder is no longer covered in paint. Some of the paint blotches change size and shape on both her and her date throughout this scene as well.
Continuity mistake: In the scene where Lois and Hal tell Malcolm he is going to the "special class", Hal notes that the pitcher of iced-tea he makes is always empty, and says, "Look at that - gone," before placing the lid back onto the pitcher. Yet, when it cuts to the wide shot of the table, the pitcher lid is by Hal's elbow. (00:17:50)
Continuity mistake: When the "Krelborne" teacher comes to the house to tell Lois that Malcolm is gifted, Lois comes to the door naked and puts her arm up on the doorway. On the shot from behind she has her hand low (about where her waist is) from the shot from the front she has her hand up high (above her head).
Visible crew/equipment: When Dewey yells for Lois because the bow was put on the present, if you look to the left of Lois, you will see a crewmember kneeling down, handing Lois the Red Dress, who is holding a bucket of water. He quickly gets out of the camera's view. [This is on the DVD of the first season. Someone said on the audio commentary that after catching it, they deliberately left it in to see if anyone would spot it. It's still a mistake, but that's why it's there.]