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Georgie: Admit it, he's adopted.
Sheldon: How can I be adopted when I have a twin sister? Think, monkey, think.
Missy: I wish I was adopted.
Mary: That can still be arranged.
As Young Sheldon is a prequel series to Big Bang Theory, this episode is at odds with episode 2-13 of Big Bang Theory, "The Friendship Algorithm," in which Sheldon is unfamiliar with books like "How to Make Friends and Influence People," which he reads in this episode of Young Sheldon, produced nine years later but taking place twenty years earlier.
Zoe Perry, who plays Sheldon's mother Mary, is the daughter of Laurie Metcalf, who plays Mary on The Big Bang Theory.