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Trivia: The first, and as of 2023 only, "Scream" movie in which someone is not killed in the opening scene. In every other "Scream" movie, two or more people are killed in the opening scene. This movie instead subverts the trope by implying Tara is killed before revealing that she survived her attack.

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Trivia: MAJOR SPOILERS: Courtney Cox was heartbroken when she read the script and saw that Dewey got killed off, since he was such a likeable, positive character. She tried to talk the directors out of actually killing him by throwing in a last-minute twist that he was still alive, such as her getting a text from him at the hospital and revealing he wasn't the one in the body-bag. However, she ultimately agreed with their decision to kill him off, since it raised the stakes.

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Trivia: When the group of friends are first introduced, if you look closely, Wes and Amber are snacking on a bag of grapes. This is a bizarrely specific reference to a scene from the first film, in which Tatum and Stu are also seen snacking on a bag of the same type of grapes. SPOILER ALERT: Just like in the original film, one of the people eating the fruit (Amber) is one of the killers, while the other person (Wes) is a victim.

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Trivia: During the scene that reveals Kirby is still alive via YouTube link, if you look very closely, you can also see a link to a YouTube conspiracy video called "Did the Real-Life Stu Macher survive?" This is an easter-egg referencing a popular fan-theory that Stu actually survived the original film and would return as the killer in a future installment.

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Trivia: Some theaters had a bonus scene that appeared right before the film started in which Ghostface (voiced by Roger L. Jackson) appears onscreen and essentially hints that he will murder anyone who gives away any spoilers.

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Trivia: When Dewey is watching Gale on the news, you can just barely hear a joke Gale makes about not wanting to have bangs ever again. This is a reference to Gale's unfortunate hairstyle in "Scream 3," which features some truly horrendous looking bangs. The look became something of a joke and later a meme, so the line was added as a subtle joke.

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Trivia: Neve Campbell almost didn't return because she didn't want to make a "Scream" movie without Wes Craven at the helm. What persuaded her was a letter she received from the new directors, explaining their passion, admiration and respect for Craven's work. The letter quickly won her over and she joined the film soon after.

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Trivia: When the dedication to Wes Craven appears at the start of the credits, you can faintly hear the sound of birds chirping. Craven was quite well-known for being an avid birdwatcher, and also fought to protect endangered species of birds. He even helped get legislation passed to ban the use of lead ammunition, which can fragment on impact and harm birds and other wildlife if accidentally ingested. The sound of birds was added as a tribute to his passion.

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Trivia: It is briefly mentioned that Sidney Prescott's former home is located on "Elm Street." This is a reference to the film "A Nightmare on Elm Street," which was directed by original "Scream" director Wes Craven. (Supposedly it was going to be mentioned in the original "Scream" as well, but the reference was cut for whatever reason).

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Trivia: SPOILERS: In the climax, Amber is soaked in hand sanitizer and set in fire. Amber's actress Mikey Madison had previously appeared in Quentin Tarantino's "Once Upon a Time in Hollywood" which came out less than three years prior... where her character is similar killed by being set on fire. (Albeit with a flamethrower.) Given Madison is only 22 and has only appeared in six live-action feature films... that's actually a pretty interesting (and darkly funny) coincidence.

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Trivia: If you look closely, you can see a box containing Tatum Riley's ashes on a shelf in Dewey's home. Tatum was of course Dewey's sister who was killed in the original movie.

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Trivia: The song "Red Right Hand" briefly plays during one of the murder scenes. The song has been featured in every other "Scream" movie except "Scream 4." (They wanted to include the song in the fourth film, but there was a copyright dispute behind the scenes and it could not be included).

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Trivia: Sidney makes a brief passing reference to having a husband named "Mark." After hearing much fan speculation, the directors confirmed that her husband is indeed Mark Kincaid from "Scream 3," who was played by Patrick Dempsey.

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Trivia: Came out almost exactly 25 years after the original. The original came out in December 1996. This film came out January 2022, with a difference of only about three weeks.

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Trivia: Originally, acclaimed director Rian Johnson was meant to have a cameo in the film as the director of the fictitious "Stab 8." He would have appeared alongside "Scream 4" co-star Hayden Panettiere as her character Kirby in a short scene. However, scheduling conflicts prevented this from happening. Nevertheless, a photo confirming that Kirby survived "Scream 4" is briefly shown, and Panettiere has a small voice-over cameo during the party scene alongside other cast and crew from the series.

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Trivia: There are tons of hidden voice cameos from former series cast/crew. Drew Barrymore provides the voice on the school loudspeaker. Matthew Lillard is the voice of "Ghostface" in "Stab 8." And during the party, Barrymore, Lillard, Adam Brody, Hayden Panettiere, Jamie Kennedy and Henry Winkler provide background voices, alongside series crew members Kevin Williamson, Marco Beltrami, Patrick Lussier and Julie Plec. Original director Wes Craven's widow Iya Craven also has a voice cameo at the party.

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Trivia: !MASSIVE SPOILERS FOR "SCREAM (2022)! Towards the end of the movie, it is revealed that Tara's friend Amber is one of the two killers. If you look at the credits, the movie was co-written by famed screenwriter James Vanderbilt... whose wife also happens to be named "Amber." This is either an incredibly bizarre coincidence, or Vanderbilt decided to include a truly odd tribute to his wife in the film by naming a psychotic killer after her... either way, it's pretty darned funny.

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Trivia: The only "Scream" movie not to be scored by Marco Beltrami, who did the music for all four of the previous films. However, new composer Brian Tyler did use some pieces and snippets of Beltrami's themes in a few key places throughout the score.

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Trivia: When Richie is watching YouTube, the video review he watches talking about "Stab 8" features a cameo from James A. Janisse and his wife Chelsea Rebecca. They are popular YouTubers who run various horror-themed shows on their channel "Dead Meat." As of 2022, they have over 5 million subscribers.

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Trivia: MINOR SPOILER ALERT FOR "SCREAM 4"/"SCREAM (2022)! When Richie is watching videos on YouTube, there is a thumbnail with an interview about a "Woodsboro Survivor," next to a picture of Kirby Reed from "Scream 4." It has been confirmed that this canonically means Kirby survived the fourth film, which has been a popular fan-theory, since she was stabbed and last seen in a pool of blood... but was shown to still just barely be breathing. (Her fate was left purposely ambiguous in "Scream 4.").

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