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Trivia: The Red Queen is played by child-actor Ever Anderson. Anderson is the daughter of star Milla Jovovich and director Paul W.S. Anderson, who are married.

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Trivia: The film was originally meant to be filmed in 2013 and released in 2014. Filming had to be delayed due to star Milla Jovovich becoming pregnant and writer/director Paul W.S. Anderson (Jovovich's husband) opting to take time off to help raise the new baby before he started work on the script.

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Trivia: Had the longest gap between sequels for the series, at just over four years since the release of the prior film. Each of the prior five films was released 2-3 years apart.

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Trivia: A number of prominent YouTube creators appear in the film as zombies in one sequence (albeit they are hard to spot, as they are under heavy makeup) - they were offered cameos in the film as part of a fun cross-promotion.

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Trivia: The first film in the series has several allusions to "Alice's Adventures in Wonderland." As a nod to that, writer/director Paul W.S. Anderson subtle modeled the first creature Alice battles - a flying, dragon-like being - after the "Jabberwocky" from the sequel novel "Alice Through the Looking Glass."

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