Continuity mistake: It was briefly stated in the second film that the T-Virus was created by Dr. Ashford to cure his daughter Angela and that the Red and White Queens were based on her. This movie contradicts that by suggesting that Dr. Marcus created the T-Virus to cure his daughter Alicia, and that the Red/White Queens were modeled after her. While the rest of the movie stays true to the continuity of the previous films, this rather obvious ret-con is still a major continuity gaff.
Continuity mistake: When Alice is narrating the previous events, we see the Red Queen appearing. We see her head appear and then the camera changes. In the second camera angle, the Queen's head appears again. (00:04:30)
Plot hole: At the beginning the Red Queen said that the last human settlement will fall in 48 hours unless Alice releases the anti-virus, however when Alice does release the anti-virus (a few seconds before the timer ends) she says it will take years for it to reach around all the corners of the globe, this does not make sense and implies that the last human settlement will fall anyway.
Suggested correction: I think you misunderstood what was happening. The human settlements were not being killed by the virus. They were being attacked by forces from the Umbrella corporation. The Red Queen explains in the final scene that once Alice killed Dr. Isaacs and released the anti-virus, she was able to take control of Umbrella and stop the attacks, saving the settlements.
That doesn't make really sense. What umbrella employees are left to do that? Also it's just bad writing.
The forces might not necessarily be Umbrella employees. They could be controlled creatures, clones or any of the other forces Umbrella has been shown to possess throughout the six movies. You can basically pick your poison, because Umbrella has been depicted as having near-limitless resources. Regardless, the movie does offer an explanation, and this particular mistake is incorrect because it is contrary to what the movie told us. Plus, like it or not, bad writing isn't necessarily a mistake in and of itself.
Continuity mistake: When the armored truck is headed to Raccoon City, there is a shot of 2 cars close together that instantly become further apart. (00:22:50)
Other mistake: Alice is running behind the armored cars. Once she manages to get on top of the car, suddenly the zombies that were only behind her and nowhere near the car are found at the sides too, attacking a guard and later Alice as well. Not possible considering if zombies were able to get there, they would have killed Alice while she was running.
Continuity mistake: There is a scene of Alice being dragged by a line behind Isaacs' tank ahead of a horde of zombies. There is no other line next to running Alice. When she climbs upon the tank to attack the guard, another line with torn hands is seen being dragged on the road, where Alice was dragged. (00:21:15 - 00:23:45)
Plot hole: At the end of Apocalypse the Umbrella corporation bombs raccoon City. It doesn't make any sense that they would do this with the entire Umbrella high command underneath the city, as we learn it is in this movie.
Suggested correction: The Umbrella high command is far underground and safe from the surface bombing. There's no mistake here.
Really? The whole point of the bomb was to destroy any evidence of what happened. That includes the hive.
The point of the bomb was to remove any trace of the virus. Meaning all the inhabitants, dead or alive. Not necessarily the Hive.
Yes but literally the head of company in Dr. Isaac's is located there. It makes no sense that they would bomb Raccoon City because according to Final Chapter they wanted the virus to spread anyway. This film franchise is filled with bad writing, crappy continuity, and plot holes.
That I can agree too. Films 4-6 have a aura about them that says "ignore everything previous, well make it up as we go along"