Question: In Resident Evil Extinction, the White Queen says Alice's blood is the cure for the whole infection. So what the heck was everyone doing the whole time? Why act so surprised to find a cure, which by the way came out of nowhere, when you were the cure the entire time?
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Answer: In all honestly... this film series isn't one to shy away from ret-conning elements of prior films. ("Ret-con" being short for "retroactive continuity" - a storytelling device in which rules and plot-points are either changed or ignored in later installments.) This just seems to be another example of a ret-con. The idea that Alice was the "cure" all along would have ended the series a lot sooner, and they wanted to make more movies, so they just sort-of "ignored" this idea in the sequels that followed "Extinction."
TedStixon