Continuity mistake: When John Candy and Steve Martin are travelling from Jefferson City, Missouri to St. Louis they are seen crossing the Mississippi River to enter downtown St. Louis. This would not have been possible unless the bus driver overshot the entire city and ended up across the river in Illinois.
Del and Neal make it to Chicago and Neal boards a commuter train for home. While on the train, he thinks about his journey with Del and certain things he said along the way. Sensing something doesn't add up, he goes back to the train station to find Del still sitting there. Del confesses that he is in fact homeless, and Marie (his wife) passed away eight years ago. Neal brings Del home with him to spend Thanksgiving with his family. In the post-credits scene, the executive who was debating which picture to choose is actually still trying to determine that, with a Thanksgiving meal present on the table in the conference room.
Del: You could kill a man like that, hitting him in the stomach. That's how Houdini died you know.
Trivia: In the scene after the plane lands in Wichita, Kansas, when the announcer comes over the loudspeaker look at the destination on the flight info display. It says "nowhere".
Question: This question is about the scene where John Candy is the driver, and Steve Martin is the passenger in the rented car. Steve is unaware at one point, that they are going the wrong way on the highway. He becomes aware, after looking out the window and down onto the shoulder of the road with the wet snow splashing up. As soon as he looks at that, he knows they are going the wrong way. What was it about the road that made him realize it?
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