Continuity mistake: Carly's shoes appear to mysteriously alternate several times between black stiletto heels and black ballet flats in-between shots during the climactic action sequence. This is most noticeable during the collapsing building sequence as well as the scene in which Carly speaks to Megatron.
Continuity mistake: In the scene with Richard Nixon speaking to the Apollo astronauts, the TV showing the phone call shows a lamp behind his head, and the seat being right behind him. But if you look at the actor sat there, there is no lamp, and the angle of the camera shows the chair would not be in shot.
Revealing mistake: In the highway chase scene, when Crowbar knocks down some signs for the other two Dreads to use them as ramps, the simple structure supporting the signs changes to a far more elaborated one when the Decepticons launch from it. The signs are even replaced with actual platforms, much longer, wider, and with different angle and separation than in the previous shot.
Continuity mistake: When Sam and Jerry Wang are in the elevator, just after the other co-workers leave, Jerry takes a drink from his milk carton, placing the straw in his mouth, from the top of the straw, down to the hinge section. The shot cuts and there is suddenly less of the straw in his mouth.