Plot hole: The sheer quantity of people that the man and boy encounter is absurd. If the majority of people worldwide are deceased, then the Americas, where the film is set, would be nearly depopulated. They should have not encountered many, if any, people simply because the survivors would either be in isolated town or cities or they would be holed in remote rural areas. Since the two largely avoid the former and the size of the latter precludes easy visitation, they shouldn't have run into anyone for most, if not all, of the film.
Plot hole: Despite supposedly being deprived of food, neither of the main characters (nor most of the minor characters) seem to display any signs of malnutrition. They both have all of their visible teeth, their stomachs are not distended and they seem to have a large amount of energy to travel by foot over lengthy distances.