Trivia: A great deal of Flint Marko/Sandman's storyline was edited out of the film by the studio due to the long run-time. One scene early in the film showed that the scientists who accidentally created Sandman were racked with guilt when they discovered they might have activated the machine with a person inside of it. Another scene had Sandman visiting a doctor researching his daughter's rare disease whom he had been corresponding with in prison. Yet another scene showed him following his daughter in a park, and morphing into a giant sandcastle that she plays with. And finally, his daughter was going to appear in the final battle, and would appeal to her father to stop hurting people and living a life of crime to get money, as she accepted that she was going to die no matter what. Her words would be what convinced him to seek forgiveness from Peter for accidentally killing Uncle Ben.
Trivia: Much of Peter's arrogance, growing violent side and showing-off in the film was in a different context in the original script. In the original script, he was starting to become comfortable now that Spider-Man was "accepted" and idolized by the public, and because his private life was doing well. He would then become arrogant as a result of this fame and adoration, as it got to his head and he begins developing a superiority complex. (Director Sam Raimi stated he was intended to be giving in to the "sin of pride.") Ultimately, he would learn humility by nearly losing MJ and losing his best friend Harry. When the studio forced Sam Raimi to add Venom into the script late in the writing process, these scenes had to be restructured at the last minute to be the result of the symbiote.
Trivia: When Mary Jane is looking through her cell phone, most of the people's names are some of the location managers.
Trivia: After the release of the film, the studio was keen to make at least two more films, and many of the actors in addition to director Sam Raimi signed contracts for a fourth and fifth installment before it was canceled. Tobey Maguire reportedly had a "play or pay" clause in his contract due to the possible time commitment they would have required, and received a rather substantial upfront payment for the movies despite them eventually being canceled.
Trivia: The script went through a lot of changes during pre-production. At one point, Sam Raimi and James Franco were working together to hone the character of Harry, and they came up with an alternate version of the story where Harry had become a violent but freewheeling playboy who had a group of super-powered showgirls (called the "Goblets") in his penthouse that he had treated with the performance enhancers and would serve as his lovers/bodyguards. Although both Franco and Raimi found the idea absolutely hilarious, it was quickly cut for obviously being way too far over-the-top.