Throughout the entire movie the size of the Event Horizon's interior versus that of its exterior is repeatedly off. Evidence of this is seen mostly with scenes that take place in the main access corridor. First off, it is made to seem that the ship has one central connecting tube, but in the exterior shots there are several tubes that make up the middle of the ship. This is pointed out when Miller is making his way across the ship to get to the air lock that Justin is about to open. Second, the length of the tube (heck even the whole ship) is too small in relation to how the ship appears from the outside. This is pointed out in a few different places in the movie - when the crew is up on bridge, then race all the way to the airlock in the middle of the main access corridor, where Justin has just closed the inner door and when the doctor is asked to go grab his med kit from medical, which is across the ship and he is gone only a few seconds, and also when Miller is running though the corridor to activate the explosive charges. Since the ship has no faster means of transportation, such as turbolifts or a tram system, they could not be covering the distance they appear to be covering in the movie.
Many of the corridors in the Event Horizon are coffin shaped - perhaps foreshadowing the fact that it is a "death" ship?