Continuity mistake: When Belini is telling Sands about Carolina, as he says "The most drop dead gorgeous woman you'll ever see", we go back to the bar where you can see the bartender push the counter back on the floor. At that time you can see all the bottles on the left side of the counter. Two shots later all the bottles has moved to the right side of the counter. (00:03:40)
Continuity mistake: When the army shoots the guards around the president, before El shows up and saves him, you can see bullets blowing off pieces of the wall behind. A second later, they disappear. The damage was CGI, and wasn't animated in all the shots.
Continuity mistake: Near the end, when blinded agent Sands is shot by one of the two bad guys in the leg, he falls towards and drops both his glasses and the gun he's holding. Then the view changes to the bad guy and in the next shot on Depp, he is holding that gun in his hand again, miraculously. (01:26:05)