Will Graham: I thought you might enjoy the challenge. See if you're smarter than the person I'm looking for.
Hannibal Lecter: Then by implication, you think you're smarter than I am, since it was you who caught me.
Will Graham: No. I know I'm not smarter than you.
Hannibal Lecter: Then how did you catch me?
Will Graham: You had...disadvantages.
Hannibal Lecter: What disadvantages?
Will Graham: You're insane.
In the scene when Will is opening the drawer of films from the Leeds home, there is clearly a copy of Mrs. Doubtfire in the left column of tapes. How can that be? Red Dragon is clearly set "several years" after 1980, as the caption says, but before the 1991 Silence of the Lambs, but "Mrs. Doubtfire" came out in 1993.
During the scene when Dolarhyde takes Reba to the zoo, the tiger she pets is not sedated. Because of the humane society they could not sedate the tiger. Instead the trainer is to the left just out of the shot keeping the tiger calm.