Character mistake: At the very beginning of the film, when Hannibal Lecter is serving dinner to his guests, one diner asks "what is this divine looking amuse-bouche" when she and the other guests have a full plate of food. An amuse-bouche is a single bite of food meant to be served at the beginning of a meal, not a plate full of food. Lecter's guests would be better educated.
Character mistake: The newspaper clipping about the Hannibal/Will encounter in the pre-credits sequence states that it could be described as a "the beginning of sorted mystery", as opposed to a "sordid mystery." (00:09:06)
Character mistake: Reba opens the door for Francis, but calls him "Ralph". (01:46:05)
Suggested correction: Reba is blind and didn't know it was Francis at the door. Ralph just dropped her off, and she thought it was him.
Character mistake: During the opening credits, one of the newspaper headlines reads "FBI Agent in Extremely Critical Condition". The story under the headline says that "local police found Dr. Hannibal Lecter fatally wounded in his Chandler Square residence", and that "the call was made by Special Agent Will Graham of the FBI". Neither was true since Lecter lived and Graham went unconscious after the stabbing.