Revealing mistake: When Ruxin's phone conversation with Kevin is overheard by Jenny, she starts an online chat with Ruxin. She sends her message, but almost as soon as she's sent it, for a fraction of a second we see "reply from Ruxin" appear on her screen, before the shot cuts to Ruxin actually seeing it and writing his reply.
Continuity mistake: In episode 1, The Draft, they show The Draft board in multiple scenes, allowing the viewers a glimpse into the rosters of most of the members of the league. In episode 3, Sunday at Ruxin's, Andre thanks Frank Gore and Andre Johnson for helping lead his team to a victory over Kevin. The mistake is that Andre did not draft either of those players; Gore was drafted by Vince, and Johnson was drafted by Ruxin. No way they traded those guys in week 2.
Factual error: Ted is holding his phone and talking to the others with the front facing camera. When he gets hit by the car the others can still see him, for that to have happened the camera would have had to land perfectly on the bottom edge, which is an impossible thing to do. (00:07:40 - 00:09:10)