The Borgias (2011)
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Starring: Jeremy Irons, Holliday Grainger, Peter Sullivan, Francois Arnaud
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Factual error: When Lucrezia is lying in bed suffering from swamp fever, probably malaria, she blames a mosquito for the disease. But she could not have known this; the discovery of the transmission of malaria by mosquitoes was not made until the late 19th century. The prevailing theory of disease transmission at the time was via miasma, or bad air.