Continuity mistake: Season 4, Episode 15, "Anchors A-Warners": When a disguised Dr. Scratchansniff is in the cruise ship's cabin searching high and low for the Warners, the bed's pillow changes location between shots. After he tosses it on top of the blue blanket, the pillow suddenly returns to its original location beside the headboard.
Continuity mistake: On their way through the Enchanted Forest in search of a red dragon's toenail clippings, Pinky and Brain reach a crossing where one sign reads Murky Mountain. In the following shot, that sign incorrectly reads Murry Mountain but soon changes back to Murky again.
Continuity mistake: When Hiskill and Eggbert greet Skippy at the theater entrance and expect to be granted access without tickets, the pair of red doors in the background change their designs in the shot where Slappy says, "Persistent little buggers, ain't they?"