Starring: Colin Baker, Jon Pertwee, Patrick Troughton, Peter Davison, Sylvester McCoy, Tom Baker, William Hartnell
Genres: Adventure, Drama, Sci-fi
The Tenth Planet - S4-E2
Question: What caused the first Doctor to regenerate? Was it old age?
Chosen answer: No, it was the result of the Cybermen's draining Earth of energy to their world, that also affected the Doctor, draining his energy as well, causing him to regenerate.
Also In the episode it's said that his body was wearing thin.
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The Doctor: You can't rule the world in hiding. You've got to come out on the balcony sometimes and wave a tentacle or two.
(Part 4) After Omega takes off his mask and looks in the mirror, when he sees that his physical body doesn't exist he puts his mask back on and screams, but when he shouts, "If I exist only by my will, then my will is to destroy," Omega's mask pops up off his face, and we can see the actor's blackened face as he shouts the last bit of his dialogue.
The first thing the Third Doctor does on-screen is collapse out of the TARDIS, which is also the last thing he does in that incarnation.