Corrected entry: Unlike the Green Goblin in the first movie, Doctor Octopus does not have superhuman strength. He should not be able to handle the amount of hits that Spiderman (who is incredibly strong) lands, especially the ones to the head. Even if Spiderman was holding back a little for some reason, Doc Oc wouldn't be able to take that much of a beating.
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Correction: In the comic books, Doc Ock absorbed some of the energy from the explosion that fused the mechanical arms to his body, thereby making it possible for him to stand up to Spider-Man in a fight. He wasn't anywhere near as strong, but was stronger than the average human. This is never explained outright in the movie, but it's implied by the very fact that Ock is going toe-to-toe with Spidey.