Plot hole: When Peyton/Darkman is showing Bridget how the liquid skin works, he drips a small amount onto his burnt finger, and it solidifies. However, when he drops it onto his finger, it magically shapes itself into a replica of a perfect, undamaged finger. This makes no sense, as it is simply a liquid and is not being molded by any forces. Hence, it should not look like a perfect finger.
Continuity mistake: When the industrial plant explodes at the end of the film, as Peyton and Angela/Jenny escape, in the wide shots you can see the flames are so big, that they actually set the actors on fire. However, in closer shots, not only are the actors not on fire, but the explosions are much smaller.