Trivia: In the beginning of the game Nate Drake is on a boat with a reporter. The name brand on their wetsuits is "Ottsel." The term "ottsel" is used in the "Jak and Daxter" games to identify what type of creature Daxter is. The "Jak and Daxter" games are made by the same company as Uncharted: Naughty Dog.
Continuity mistake: No matter what weapon you are holding before a cut scene appears, the cut scene will always show a pistol, even if you were holding a rifle.