Plot hole: Drake is supposed to be discovering lots of things in the game for the first time, yet every secret door or area he explores, there's always enemies there. If he's supposed to be the first one there, how can the enemies be there before him?
Trivia: In the beginning of the game Nate Drake is on a boat with a reporter. The name brand on their wetsuits is "Ottsel." The term "ottsel" is used in the "Jak and Daxter" games to identify what type of creature Daxter is. The "Jak and Daxter" games are made by the same company as Uncharted: Naughty Dog.