Factual error: Whenever the fire extinguisher is activated for a jet engine, that engine becomes inoperable. In the movie, the co-pilot first activates the extinguisher for the left engine, and 30 seconds later, for the right engine. At that point, both engines should be shut down. However, the engines are still operating (and revving up) and Whitaker even asks Margaret to apply full power, which is also audible. (00:23:00)
Character mistake: When Whip is in the hospital, standing straight in front of the camera is a ridiculous nurse; she takes down the empty IV bag and pulls the bag away from the IV line, she drops the bag on the floor, a big no-no, but try as she might she can't seem to get the spike to go into the new bag. While she's doing all this, she's waving that sterile spike everywhere, touching everything she can, including herself, and picking up germs that will go straight into Whip's IV line, and into his body, when, finally she gets that infected spike into the infected new bag.
Factual error: During the emergency, Whip instructs Ken to dump fuel, and fuel is seen spraying out of the nozzle on the wing. MD-80 family aircraft are not equipped with fuel dump capabilities.
Character mistake: When Whip is in hospital, a nurse comes in with the others but what she does with the IV is all wrong. First: she tosses the empty IV bag onto the floor - you never do that - and then she proceeds to tug continually on the base of another IV bag, trying to get the IV line out of the bag - this she does not succeed in doing.
Factual error: During the pre-flight scene, in the exterior shot panning from the control tower down to the aircraft parked at the gate, the sign on the jetway indicates gate A27, when there is in fact no such gate at Orlando International Airport.
Continuity mistake: When Whip goes to see his ex-wife and son, he parks with a fire hydrant by the front right fender. He takes a drink, gets out of the car, and the fire hydrant has vanished.
Factual error: When Denzel checks his iphone, the lock screen shows a date of October 20 and the time is 1:17. After unlocking the screen, the calendar icon on the phone shows the 8th as the date, and the time as 8:52. The battery remaining also changes.
Factual error: When Whip finishes his walk-around, he meets his First Officer and asks: "have we met before?" or something like that. In the real life, you meet your crew in the crew room, give them a thorough briefing, so when you go to an airplane, you already know the people you're going to work with. That's the place you introduce yourself, not the flight deck. It's impossible to meet your FO on the flight deck, without having met him first in the briefing room.