Factual error: In a very early scene, just as the young girl is pulling a cellphone out of her vagina, if you look closely you can see that the "cellphone" she is holding is actually an iPod Nano 5th generation, which does not make phone calls. (00:04:20)
Continuity mistake: When Machete is picked up by Booth in the S-class, the car changes from an S500 to an older generation S-class, and then switches back for the rest of the film. The footage was from the trailer being edited in.
Padre Benito del Toro: I absolve you of all your sins. Now get the fuck out.
Trivia: This is the second time that actor Danny Trejo has played a character named Isador "Machete" Cortez, the first time being in "Spy Kids." It's debatable whether or not they are the same character.