Trivia: This is the second time that actor Danny Trejo has played a character named Isador "Machete" Cortez, the first time being in "Spy Kids." It's debatable whether or not they are the same character.
Continuity mistake: When Machete is picked up by Booth in the S-class, the car changes from an S500 to an older generation S-class, and then switches back for the rest of the film. The footage was from the trailer being edited in.
Padre Benito del Toro: It's not safe for you to be here.
Machete: I'm not looking for "safe."
Padre Benito del Toro: No, I mean it's not safe for me for you to be here!