Trivia: This is the second time that actor Danny Trejo has played a character named Isador "Machete" Cortez, the first time being in "Spy Kids." It's debatable whether or not they are the same character.
Continuity mistake: After Machete's failed sniper shot on the roof-top, he is chased onto a rooftop where he kills a bunch of people. After he has killed everybody a splat of blood randomly appears on the ground.
Padre Benito del Toro: It's not safe for you to be here.
Machete: I'm not looking for "safe."
Padre Benito del Toro: No, I mean it's not safe for me for you to be here!