Continuity mistake: When Eduardo finds the letter on the mantlepiece about them apparently stealing the idea for Facebook and asks Mark if they did or not, he places a bottle on the mantlepiece just before he finds the letter. This bottle rotates slightly between shots without him touching it after placing it down.
Continuity mistake: When Sean shows up at the Palo Alto house Mark goes to the refrigerator and tosses Sean a beer. Right after this he tosses a beer to Sharon, Sean's friend. The bottle shatters on the wall and a few pieces get stuck in between the bricks. When the angle changes all of the pieces are instantly gone. A few seconds after this, right after Sean talks to the "wired in guy" the pieces are back.