Continuity mistake: When Kirk Lazarus tricks Tugg Speedman into giving him the map, in one shot one of the shotgun shells on his back in his artillery belt is out of place and not lined up with the rest of them. In the very next shot, all the shotgun shells are lined up and in place evenly.
Continuity mistake: When the actors (minus Tugg Speedman) have set up camp for the night, close up shots of Kirk Lazarus show him petting the water buffalo, while all other shots show the water buffalo completely out of arm's length. Lazarus does not move around in this scene to make this possible.
Revealing mistake: During the helicopter escape scene before Tran fires the rocket at them, you can see Cody's hair showing up a bright green from the green screening. You see it several times, but most pronounced at the moment he and Portnoy see Peck arrive with the TiVo.
Continuity mistake: Just after the ambush scene, Speedman walks towards Lazarus and speaks to him, the camera viewing from behind Speedman's point of view. The very next shot shows it from behind Lazarus with Lazarus looking back in suspicion. There is a noticeable difference in the level of day light between these shots. Like an hour has passed with the sun going down.
Other mistake: After the part where Cockburn explodes to bits on a mine, Speedman finds and picks up his walkie talkie as Cody is trying to communicate through it. The device is not only smoldering hot, causing Speedman to have to drop it, but it even appears to be melted. With the amount of heat it went though, much less the jar of the explosion, it should not have been still working at all. The 'actors' should not have heard Cody though it. Not only this, but the establishing shot of it on the ground shows the antenna snapped and broken over.
Plot hole: In the scene where Speedman and Lazarus are discussing their acting and Lazarus tells him to never go full retard. It shows these two leading the group, however they stop and talk for quite a while, and the rest of the group are nowhere to be seen until Speedman and Lazarus start moving again. The group finally caught up with them. If at this time, Speedman was still leading the way with the map, how could the group even find these two after being left behind enough distance that this conversation could take place?
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Factual error: In the helicopter scene at the end of the movie, after the RPG is launched at the Huey Helicopter, Danny McBride pulls back violently on the cyclic stick between his legs to avoid the rocket, but instead of moving backwards, the helicopter ascends in altitude, which would only happen when the pilot pulls up on the collective stick, located on his left. Pulling back on the cyclic with that amount of force would have certainly caused the helicopter to crash into the trees located behind the aircraft.