After a female doctor finds a cure for cancer, the cure mutates into a deadly virus that affects everyone. Lt. Col. Robert Neville is working on the cure when he has to get his family out of Manhatton, because they are closingit off. Once all of the uninfected are gone, only soldiers and the infected remain. Neville tries desperately to find a cure using his blood and find other survivors. When he captures the Alpha Female, the Alpha male doesnt like that very much. Neville is running out of time and hope as the darkness closes in.