Neville is strung up in one of his traps. He cuts himself free but stabs himself in the leg by accident. Some of the dog zombies come along and Sam gets injured with Neville narrowly escaping with his life. He tries to save Sam but when she is about to turn into one of the infected he is left with no choice but to kill her. He then goes on a vengeful killing spree of the infected in his car, running them over. His car crashes and, just as one of the infected is about to kill him, he is saved by another survivor named Anna and her son Ethan. She drives back to Neville's home, the infected following, unbeknownst to her. She patches up his leg but the house is attacked by the infected. The three of them take refuge in Neville's lab and he realizes that the cure is working on the infected woman. He gives a sample of the cure to Anna and has her take cover in a coal chute. He then pulls out a picture of his family and a hand grenade, pulling the pin of the grenade and charging the infected leader with it as he breaks through to the lab, sacrificing himself and killing a hell of a lot of infected along the way. Anna and Ethan survive and drive to a survivors colony, handing over the cure to the leader. She then states in a voice over that Neville sacrificed himself for humanity and that because of his cure humanity was able to rebuild, establishing his legend. Alternate ending: The infected people attack Neville's lab and he hands over the infected female he's been working on to the leader (a.k.a. the alpha male) and the infected leave. Neville, Anna and her son walk along the George Washington Bridge, hoping to find survivors...
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