A young girl (Jennifer Carpenter) dies under the care of her parish priest (Tom Wilkinson). While attending college, Emily believed she became possessed. After medical care ceases to work, she turned to her faith. In the care of her priest she dies and he goes on trial for her death. He is represented by a career-minded and driven lawyer (Laura Linney) who does not believe in God. Thus is the story of Emily Rose, told by those in the trial and the priest who watched her through her possession.