Lincoln Rhyme (Denzel Washington), once field forensics specialist extrordinaire, is now a quadropelegic. He has to depend on his nurse (Queen Latifah) and his high-tech room set-up for everything. When a series of grisly New York killings take on a twist, Rhyme must use the able-bodied Amelia Donohughy (Angelina Jolie) to help him to race against time to before the Bone Collector claims his next victim.
Factual error: At the end, Denzel Washington's character has a Grand Mal Seizure. But he is supposed to have a spinal cord injury. He can still have seizures in that the electrical impulses in his brain go haywire, but if he has a spinal cord injury that prevents him from moving, the seizure action in his brain wouldn't translate to his body jerking and shaking.
Lincoln Rhyme: Whatever happened to your father doesn't mean it's gonna happen to you. You're a great cop. You'd make a terrific detective. It's a gift. Don't throw it away.
Trivia: The movie makers really wanted the audience to believe that Michael Rooker was the killer, rather than Leland Orser. So much so that Rooker actually played the killer in almost all the scenes where the killer wears a mask. When you see the eyes of the killer through the mask the eyes are Rooker's.