Harry Burns and Sally Albright meet in the late 70's as they drive together to New York City after college. They dont' really get along, and have a big discussion about how men and women can never really be friends because "the sex thing gets in the way." They see each other again after 5 years, and still don't get along. Another 6 years go by, Harry has been married but is getting divorced, and Sally just broke up with her boyfriend of 6 years. This time, they become friends, but their friendship intensifies, and they wind up having sex, which does indeed get in the way of their friendship.