Continuity mistake: When Dustin Hoffman (dressed as Dorothy) goes to babysit for Jessica Lange he takes a bunch of flowers as a present. Jessica Lange takes them from him and throws them on the kitchen table. Then she walks into the kitchen (shot from different angle) still holding the flowers and throws them on the table (again).
Continuity mistake: When Terri Garrett comes to the apartment and Michael is in makeup he leaves his wig, earrings, shoes and purse in the dining room. Bill Murray picks up the shoes and purse, but not the wig or earrings. He places those items in the bedroom, however when he returns the wig is gone, and only the earrings remain, which he disposes of in a jar.
Continuity mistake: At the dinner table when everyone's at the house in upstate NY, the piano in the background is a console model but later as Tootsie plays the piano, it's become an old upright.
Continuity mistake: When Jessica Lange has Dustin Hoffman over to her place for dinner, she is wearing sweats and her hair is in a ponytail. But in one shot, where she is mixing food in a bowl with her hands, she has on a T-shirt and jeans, and her hair is in a French braid. In the following scenes, she is back in sweats and the ponytail.