Directed by: Gore Verbinski
Starring: Jason Isaacs, Dane DeHaan, Mia Goth, Ivo Nandi
Volmer: Do you know what the cure for the human condition is? Disease. Because that's the only way one could hope for a cure.
Volmer: Most of my patients have done extraordinary things. Built vast fortunes, commanded great empires... but at a terrible cost. They have no-one who cares from them.
Continuity mistake: Early in the film, Lockhart tells his driver to take him to a hotel, and they start down a winding Alpine mountain road before suddenly slamming into a deer. The Mercedes sedan goes off the road, airborne, into the forest, rolling many times before crashing down hard on its side. But, when the camera cuts back to the mortally-injured deer in the road, we see the Mercedes is wrecked on the road shoulder only about 30 feet away from the animal.
Trivia: When Lockhart is in the sensory deprivation tank, the nurse that does a poor job of keeping an eye on him is reading "Der Zauberberg" by Thomas Mann, which obviously has at that point a common premise with the movie (the main character goes to a sanatorium in the Alps just as a visitor but ends up as an inmate). The novel was inspired by Mann's visit to his wife at a Swiss sanatorium which happened in 1912, same year as the picture fully unveiled in the finale.
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Answer: As a result of the tortures he endured at the hospital, Lockhart lost his mind. At the end, as he pedals away from the hospital and down the road, he grins maniacally because he is now quite mad.
Charles Austin Miller