Other mistake: In the beginning of the film when the stage coach is approaching Minnie's haberdashery, a well-worn horse path when approaching the haberdashery but it's been snowing a long time, and there is not a lot of traffic going to the haberdashery so this path should not be so worn.
The Hateful Eight (2015)
1 other mistake
Directed by: Quentin Tarantino
Starring: Samuel L. Jackson, Kurt Russell, Tim Roth, Channing Tatum, Jennifer Jason Leigh
Genres: Western
Revealing mistake: When Warren begins shooting Bob, a massive blood spurt is shown each time he shoots him. Each time he is shot, the blood spurts don't line up with the area where Warren shoots at. The first time Warren shoots Bob, the gun is showing firing at his stomach, but the blood is shown spurting from his chest and the second time he shoots Bob, the gun is fired at the top of his chest, but the blood spurts come from a couple of inches below where he was shot. (01:57:00)
John Ruth: No one said this job was supposed to be easy.
Major Marquis Warren: Nobody said it's supposed to be that hard, either.
Trivia: Towards the end of the movie. When Major Marquis runs out of ammo, in the slow motion scene. The score is taken from John Carpenter's "The Thing", another movie staring Kurt Russell.
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Answer: It's not PURELY fictional, as plenty of poisons lead to vomiting and bleeding (cyanide, arsenic, etc.), but Tarantino, as is his wont, definitely takes some artistic license and kicks it up several notches for dramatic/gross-out effect.