Blind Al: Looks aren't everything.
Deadpool: Looks ARE everything! Ever heard Dave Beckham speak? It's like he mouth-sexed a can of helium. You think Ryan Reynolds got this far on a superior acting method?
Blind Al: Love is blind, Wade.
Wade Wilson: No, you're blind.
In the scene near the end where Ajax has a knife in the side of Deadpool's head and is punching him, later Deadpool pulls the knife out. In a follow up shot there is no hole in the mask where the knife was, but in a later shot the hole is there.
In the 'happy Lent' scene, Wade is reading the Mario Lopez autobiography. Mario Lopez filmed a promotion with Ryan Reynolds where they pretended the movie was going to be toned down to a PG-13, which would have infuriated fans, before revealing the true R rating.