Continuity mistake: When Doc has just consumed the 'wake up juice' and runs out of the bar and dunks his head in the horse trough, Marty and the bartender come out after him. You can see that Doc is now soaked and a trail of water is on the ground behind him from a previous take of Marty dragging him back in the bar, which hasn't happened yet at this stage. Only really noticeable in the cropped version. (01:20:05)
Continuity mistake: When Doc and Marty are chasing the train on horseback, Doc gets on the train first and his horse pulls forward. Then when the camera shows Marty on his horse, another horse can be seen in front of him. When Marty jumps on the train, his horse falls back. But in the next shot you can still see the horse as it moves off camera. (01:30:55)
Continuity mistake: When the Doc enters the destination time into the time circuits when he is sending Marty to 1885 from 1955, the time/date etc. Go in as he's typing it. However, in the previous films and later in the 3rd film when traveling back to 1985, the enter button must be pressed before anything appears for the destination time.
Continuity mistake: In 1885 Hill Valley, the hills are shown to be almost directly behind the courthouse, however in the previous films there was some distance between the two. This was likely due to the different shooting locations. (00:26:40)
Continuity mistake: In the scene where Marty is driving the black Toyota pickup at the end of the movie, the truck's registration plate is missing - it can be seen when the truck is in the garage at the start of the film. Also the driver's door quarter light (vent window) is open. When we see the inside of the door it is closed. (01:41:45)