Audio problem: When old and young Biff listen to the end of the football game in the car, as the two are talking back and forth about how old Biff knew what the results would be, the sound of the announcer on the radio lowers and then suddenly disappears altogether... yet neither of them physically turn the radio down or off. The two are shown the whole time talking to each other and both their hands are away from the radio.
Other mistake: Griff enters Cafe 80s and tells Grandpa to wax the car. Grandpa stands up and walks to the door, but Griff keeps looking at where he was standing before. This was due to the VistaGlide system of filming an empty space without stunts that could serve as cues as to where to look at.