Question: After a phone call, William tries to take his wife and daughter and leave the town. In the car, his wife asks him why he is a such a hurry to leave, he says "Leaving. That's what they want. So they can destroy my life's work." Who does he refer to and why would "they" try to destroy his life's work?
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Answer: He is talking about the Umbrella corporation stealing his work, specifically, the G-Virus, so they can weaponize the virus. If the process goes well, Umbrella will take credit for it, but if the process goes poorly, Umbrella will blame Birkin for the failure, either way, Birkin loses.