The Benders - S1-E15
Continuity mistake: When the Deputy handcuffs Dean to the car door handle, he uses a small radio/cell antenna from the car to pick his handcuff lock (attached to his wrist), just as the bad guys walk toward the car. When the bad guys get to the car Dean is gone and so are the handcuffs (including the cuff that was attached to the door handle). Dean did not have time to pick both handcuff locks.