Deliberate mistake: In the scene where Maya is looking for Rodney at the party and he scampers off into the bathroom, he miraculously climbs on top of a toilet in a matter of seconds (which isn't actually shown). There is no way a guinea pig could do this.
Trivia: Eddie Murphy had a big problem while working on this movie: He is very squeamish about most animals. It is even so serious that he flatly refused to do a scene involving an alligator. Hence, most shots with animals were done via blue-screen technique.
Trivia: The scene where Dr Dolittle awakes to find the guinea pig in the bed with him looks like an homage to the horse's head scene in The Godfather. The way he screams, and the way the camera cuts to an external shot, is an exact copy.
Squirrel #1: ...Bagel chips. Squirrel #2: Back off, or you'll find your nuts in a tree. Squirrel #1: Ow! Where's the love?
Lucky: A little girl once called me "Please mommy, not him."
Woman: Need some help? Dr. John Dolittle: Oh, no, I'm - we're - we're fine. I'm just stretching my legs a little here. Rodney: Ask her if she's got any lettuce. Dr. John Dolittle: Shut your mouth. Shut your furry little mouth right now.
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